Cardiology Fellowship - More Information

Scholarly activity and application details

Scholarly Activity

2022

Heart and Vessels

Mumtaz S, Sharma M, Fu MP, Sharma A, Mir J, Rehman A, & Vranian M

Prognostic role of diuretic failure in determining mortality for patients hospitalized with acute decompensated heart failure. doi: 10.1007/s00380-022-02042-x

2018

Journal of American College of Cardiology-Imaging

Sperry B, Vranian M, Tower-Rader A, Hachamovitch R, Hanna, M, Brunken R, Phelan D, Cerquera M, Jaber W

Regional variation in Technetium pyrophosphate uptake in transthyretin cardiac amyloidosis and impact on mortality doi: 10.1016/j.jcmg.2017.06.020.

Journal of Nuclear Cardiology

Vranian M, Sperry B, Hanna M, Hachamovitch R, Ikram A, Brunken R, Jaber W

Technetium pyrophosphate uptake in transthyretin cardiac amyloidosis: Associations with echocardiographic disease severity and outcomes. doi: 10.1007/s12350-016-0768-9.

2016

Journal of the American College of Cardiology (JACC)

Sperry B, Ikram A, Hachamovitch R, Valent J, Vranian M, Phelan D, Hanna M

Efficacy of Chemotherapy in Light Chain Amyloidosis in Patients Presenting with Symptomatic Heart Failure doi: 10.1016/j.jacc.2016.03.593

International Journal of Cardiology

Sperry B, Vranian M, Hachamovtich R, Joshi H, McCarthy M, Ikram A, Hanna M

Are classic predictors of voltage valid in cardiac amyloidosis? A contemporary analysis of electrocardiographic findings. doi: 10/1016.j.ijcard.2016.4.030

Journal of American College of Cardiology-Imaging

Sperry B, Jones B, Vranian M, Hanna M, Jaber W

Recognizing Transthyretin Cardiac Amyloidosis in Patients with Aortic Stenosis: Impact on Prognosis doi: 10.1016/j/jcmg.2015.10.023

Journal of the American Heart Association

Sperry BW, Vranian MN, Hachamovitch R, Joshi H, Ikram A, Phelan D, Hanna M

Subtype-Specific Interaction and Prognosis in Cardiac Amyloidosis. doi: 10.1161/JAJA.115.002877

2015

Current Cardiology Reports- (invited review article)

Vranian MN, Sperry BW, Valent J, Hanna M

Emerging Advances in the Management of Cardiac Amyloidosis. doi: 10.1007/s11886-15-0653-1

2013

American Journal of Cardiology

Vranian M, Keenan T, Blaha MJ, Silverman MG, Michos E, Minder M, Blumenthal R, Nasir K, Menghelo R, Santos R

Impact of Fitness Versus Obesity on Routinely measured Cardiometabolic Risk in Young, Healthy Adults doi: 10.1016/j.amjcard.2012.12.022

2005

Journal of Chromatography B

Farthing D, Sica DA, Fakhry I, Larus T, Ghosh S, Farthing C, Vranian M, Gehr T

Simple HPLC-UV Method for Determination of Iohexol, Iothalamate, P-aminohippuric Acid and n-acetyl-P-aminohippuric Acid in Human Plasma and Urine with ERPF, GFR and ERPF/GFR Ratio Determination Using Colorimetric Analysis J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 5;826(1-2):267-72.

2019

Whole Food For a Whole Life

Wenger, C.

Lancaster Physician: Official Publication of Lancaster City & County Medical Society Winter 2019; 19-20. http://www.nxtbook.com/hoffmann/Lancaster_Physician/LPWinter2019/index.php#/1

2018

Does a Spoonful of Sugar Help (More) Medicine Go Down?

Wenger, C.

The Journal of Lancaster General Hospital 2018; Vol 13; No 3:68-72.

http://www.jlgh.org/Past-Issues/Volume-13-Issue-3/Spoonful-of-Sugar.aspx

Bill seeks to improve health of food stamp participants

Wenger, C.

Lancaster Newspaper, Opinion editorial, August 2018.

https://lancasteronline.com/opinion/columnists/bill-seeks-to-improve-health-of-food-stamp-participants/article_b3896bf6-96a8-11e8-bfd2-071e0bdce2ab.html

2016

The 2015 Dietary Guidelines for Americans: Reading Between the

(Guide) Lines

Wenger, C.

The Journal of Lancaster General Hospital 2016; Vol 11; No 1:18-23.

http://jlgh.org/Past-Issues/Volume-11---Issue-1/2015-Dietary-Guidelines.aspx

2015

Can you go sugar-free for 10 days?

Wenger, C.

Wellness & Prevention blog, May 2015

http://lghealthhub.org/Wellness-Prevention/Can-you-go-sugar-free-for-10-days

2014

On Trial: Saturated Fat: Proven Villain or Medical Myth?

Wenger, C.

The Journal of Lancaster General Hospital 2014; Vol 9; No 3:69-74.

http://jlgh.org/Past-Issues/Volume-9---Issue-3/On-Trial--Saturated-Fat.aspx

2012

Basic EKG Interpretation

Wenger, C.

August 2012

Link

2009

Safety of high dose beta blockade for coronary computed

tomographic angiography

Brofferio, A; Marwaha, A; Sarin, S; Mascarenhas, V; Wenger, C; Qureshi, A; Woomert, C; Go, D; Clark, K; Nassef, AL; Shirani, J.

Journal of Invest Med 2009; 57 (3):525.

2008

Clinical Significance of Epicardial Fat using Cardiac Multi-Slice

Computed Tomography

Sarin S, Wenger C, Marwaha A, Qureshi A, Go D, Woomert K, Clark K, Shirani J.

The American Journal of Cardiology 2008;Vol 102;No. 6:767-771

2007

Quantification of Epicardial Fat using Cardiac Multi-Slice Computed

Tomography

Sarin S, Wenger C, Marwaha A, Qureshi A, Go D, Woomert K, Clark K, Shirani J.

Journal of Cardiovascular Computed Tomography 2007;Vol 1;No.1 (suppl): S16-17.

2006

Anatomy in a New Curriculum: Facilitating the Learning of Gross

Anatomy using Web Access Streaming Dissection Videos

Dilullo C, Coughlin P, D’Angelo M, McGuinness M, Bandle J, Slotkin E M., Shainker S, Wenger C, Berray S

Journal of Visual Communication in Medicine 2006;Vol 29;No.3:99-108.

2011

Sudden Cardiac Death

Lee JH and Gleva M.

The Washington Manual Cardiology Subspecialty Consult, 3rd ed. Lippincott Williams and Wilkins. Philadelphia, PA. In press 2011.

Pacemakers

Lee JH and Smith TW.

Tarascon Pocket Cardiologica, 1st ed. Jones and Bartlett Learning. Burlington, MA. 2011

2008

Diabetic Ketoacidosis Associated with Aripiprazole

Makhzoumi Z, McLean L, Lee JH, Ibe A.

Pharmacotherapy 2008; 28; 1198-1202.

Allergic and Immunologic Disorders

Lee JH and Bollinger M.

NMS Medicine, 6th ed. Lippincott Williams and Wilkins. Philadelphia, PA.

2001

Do high glucose levels have differential effects on FDG uptake in

inflammatory and malignant disorders?

Zhuang HM, Cortes-Blanco A, Pourdehnad M, Adam LE, Yamamoto AJ,

Martinez-Lazaro R, Lee JH, Loman JC, Rossman MD, Alavi, A.

Nuclear Medicine Communications 2001; 22; 1123-1128.

1998

Lexical Semantic and Associative Priming in Alzheimer's Disease

Glosser G, Friedman RB, Grugan PK, Lee JH, and Grossman M.

Neuropsychology 1998; 12; 218-224.

2019

Heart failure post-discharge clinic: a pharmacist-led approach to

reduce readmissions

Al-Bawardy R, Cheng-Lai A, Prlesi L, Assafin M, Xu S, Chen K, Tandan S, Aneke CS, Murthy S, Piña IL

Curr Probl Cardiol Jan 5 2019 [EPub ahead of print]

2018

Eosinophilic myocarditis with rapid progression to cardiogenic shock,

managed with mechanical support and high-dose corticosteroids

Tandan S, Meltzer SN, Davila CD, Konstam MA, LeWinter MM

Circ Heart Fail 11(6):e004910

2016

Surgical management of interventricular septal rupture

Alkhalil I, Barrett T, Tandan S, Hamlin MP, Schmoker JD, Hopkins WE

Coron Artery Dis 27:618-620.

2014

Calcineurin-mediated ion channel regulation in heart

Wang Y, Tandan S, Hill JA

Trends Cardiovasc Med 4:14-22

A rare finding on liver explant

Tandan S, Sun K, Gaglio PJ

Clin Gastroenterol Hepatol 12:e85-86

2012

STIM1-dependent store-operated Ca2+ entry is required for

pathological cardiac hypertrophy

Luo X, Hojayev B, Jiang N, Wang ZV, Tandan S, Rakalin A, Rothermel BA, Gillette TG, Hill JA

J Mol Cell Cardiol 52:136-147

2010

Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type Ca2+ channel Cav1.2

Xu H, Ginsburg KS, Hall DD, Zimmermann M, Stein IS, Zhang M, Tandan S, Hill JA, Horne MC, Bers D, Hell JW

Biochem 49:10298-10307

2009

Physical and functional interaction between calcineurin and the

cardiac L-type Ca2+ channel

Tandan S, Wang Y, Wang TT, Hall DD, Hell JW, Luo X, Rothermel BA, Hill JA

Circ Res 105:51-60

2008

CaMKII-dependent remodeling of Ca2+ current in pressure-overload

heart failure

Tandan S, Wang Y, Cheng J, Chen G, Nguyen L, Sugianto J, Johnstone JL, Hill JA

J Biol Chem 283:25524-25532

2006

Transient-outward K+ channel inhibition facilitates L-type Ca2+

current in heart

Wang Y, Cheng J, Tandan S, Jiang M, McCloskey DT, Hill JA

J Cardiovasc Electrophysiol 17:298-304

2005

Identification of mutations from phenotype-driven ENU mutagenesis

in mouse chromosome 7

Culiat CT, Klebig ML, Liu Z, Monroe H, Stanford B, Desai J, Tandan S, Hughes L, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Li Q

Mamm Genome 16:555-566

Sponsored clinical research

DAPA ACT HF-TI MI 68: A Multicenter, Randomized, Double-Blind, Parallel Group, Placebo-Controlled Trial to Evaluate the Effect of In-Hospital Initiation of Dapagliflozin on Clinical Outcomes in Patients with Heart Failure with Reduced Ejection Fraction Who Have Been Stabilized During Hospitalization for Acute Heart Failure Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure - Thrombolysis in Myocardial Infarction 68. Sponsor, TIMI Study Group. NCT #04363697

TAVR Unload: Transcatheter Aortic Valve Replacement to Unload the Left Ventricle in Patients with Advanced heart failure: a randomized trial. Sponsor, Cardiovascular Research Foundation (CRF). NCT #02661451

2023

CT-Guided Direct Current Cardioversion for Atrial Arrhythmias During

the Covid-19 Pandemic

Madhi Veillet-Chowdhury MD, Ghaith Sharaf Dabbagh, Stewart M. Benton, April M. Hill, Jefferson H. Lee, Matthew J. Singleton, Gregory P. Fazio, James E. Harvey, Habib Samady, David Singh, Mohammed Y. Khanji, Saman Nazarian, Francesca Pugliese, Edmond Obeng-Gyimah, Brian T. Schuler, and C. Anwar A. Chahal

JACC: Cardiovascular Imaging Volume 16, Issue 1, January 2023. doi: 10.1016/j.jcmg.2022.08.009

2020

Challenging Left Atrial Appendage Closure Using Intraprocedural

Cardiac CT Guidance

Mahdi Veillet-Chowdhury MD, Stewart Benton Jr. MD, James E. Harvey MD, MSc, William Nicholson MD, Brian Schuler MD

JACC: Cardiovascular Interventions Volume 13, Issue 10, May 2020. doi: 10.1016/j.jcin.2020.01.237

2023

Wolff-Parkinson-White and the risk of sudden cardiac death – an epidemiological study from Olmsted County Minnesota

Chahal CAA et al.

Journal of the American College of Cardiology

A customizable and peer-reviewed curriculum for cardiovascular genetics and genomics

Landstrom AP*, Chahal CAA*, Roden, D. Ho C, Shah S

Circulation (November 2023, in press)

Assessing heterogeneity on cardiovascular magnetic resonance imaging–A novel approach to diagnosis and risk stratification in cardiac diseases. Hesse K, Khanji MY, Aung N, Petersen SE*, Chahal CAA*. European Heart Journal Cardiovascular Imaging (October 2023, in press)

Reevaluating the Incidence and Prevalence of Clinical Hypertrophic Cardiomyopathy: An Epidemiological Study of Olmsted County, Minnesota. Karim S*, Chahal CAA*, Sherif AA, Khanji MY, Scott C, Chamberlain AM, Ommen SR, Gersh BJ, Geske J, Somers VK, Brady PA, Lin G. Mayo Clinic Proceedings (2023, in press)

Surgical management of atrial fibrillation in patients undergoing cardiac surgery: a systematic review of clinical practice guidelines and recommendations. Kumar NS, Chahal CAA, Awad WI. European Heart Journal - Quality of Care and Clinical Outcome 2023 PMID: 37873664

Predictors of morbidity and in-hospital mortality following procedure-related cardiac tamponade. Deshpande S, Swatari H, Ahmed R, Collins G, Khanji MY, Somers VK, Chahal AA, Padmanabhan D. Journal of Arrhythmia 2023 PMID: 37799802

Genetic Mechanisms Underlying Arrhythmogenic Mitral Valve Prolapse: Current and Future Perspectives

Levy S, Sharaf Dabbagh G, Giudicessi JR, Haqqani H, Khanji MY, Obeng-Gyimah E, Betts MN, Ricci F, Asatryan B, Bouatia-Naji N, Nazarian S, Chahal CAA.

Heart Rhythm O2 2023 PMID: 37744942

Predicted Damaging Variants in Cardiomyopathy Genes Prognosticates Mortality and Composite Outcomes in UK Biobank

Asatryan B, Shah RM, Sharaf Dabbagh G, Landstrom A, Darbar D, Khanji MY, Lopes LR, van Duijvenboden S, Muser D, Lee AM, Haggerty CM, Arora P, Semsarian C, Reichlin T, Somers VK, Owens AT, Petersen SE, Deo R, Munroe PB, Aung N, Chahal CAA.

JACC HF 2023 PMID: 37715771

Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association

Landstrom AP, Chahal AA (Vice Chair), Ackerman MJ, Cresci S, Milewicz DM, Morris AA, Sarquella-Brugada G, Semsarian C, Shah SH, Sturm AC; American Heart Association Data Science and Precision Medicine Committee of the Council on Genomic and Precision Medicine and Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Hypertension; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Peripheral Vascular Disease; and Stroke Council.

Circulation: GPM 2023 PMID: 36970980

Beyond gene-disease validity: capturing structured data on inheritance, allelic-requirement, disease-relevant variant classes, and disease mechanism for inherited cardiac conditions

Josephs KS, Roberts AM, Theotokis P, Walsh R, Ostrowski PJ, Edwards M, Fleming A, Thaxton C, Roberts JD, Care M, Zareba W, Adler A, Sturm AC, Tadros R, Novelli V, Owens E, Bronicki L, Jarinova O, Callewaert B, Peters S, Lumbers T, Jordan E, Asatryan B, Krishnan N, Hershberger RE, Chahal CAA, Landstrom AP, James C, McNally EM, Judge DP, van Tintelen P, Wilde A, Gollob M, Ingles J, Ware JS.

Genetics in Medicine (2023 in press) preprint PMID: 37066275

DiscoVari: a web-based precision medicine tool for predicting variant pathogenicity in cardiomyopathy- and channelopathy-associated genes Kurzlechner LM, Kishnani S, Chowdhury S, Atkins SL, Moya-Mendez ME, Parker LE, Rosamilia MB, Tadros HJ, Pace LA, Patel V, Chahal CAA, Landstrom AP.

Circulation: GPM 2023 PMID: 37409478

Revisiting Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Current Practice and Novel Perspectives

Ottaviani A, Mansour D, Molinari LV, Galanti K, Mantini C, Khanji MY, Chahal AA, Zimarino M, Renda G, Sciarra L, Pelliccia F, Gallina S, Ricci F.

Journal of Clinical Medicine 2023 PMID: 37685777

Predicting left ventricular hypertrophy from the 12-lead electrocardiogram in the UK Biobank imaging study using machine learning

Naderi H, Ramirez J, van Duijvenboden S, Ruiz Pujadas E, Aung N, Wang L, Chahal CAA, Lekadir K, Petersen SE, Munroe PB

European Heart Journal - Digital Health 2023 (in press)

Editorial commentary: Genomic and precision medicine provides deeper insights into the genetic basis of diverse JPH2-mediated phenotypes

Patel V, Chahal CAA.

Trends Cardiovasc Med. 2023 Jan;33(1):11-12. PMID: 34965474

A Predictive Model of Stroke in Heart Failure with Preserved Ejection Fraction without Atrial FibrillationLam P, Chahal CAA

Circulation: Heart Failure 2023 (in press) PMID: 37350258

Improving risk stratification of sudden cardiac death in ischemic cardiomyopathy beyond the contemporary ejection fraction: can cardiac magnetic resonance help?

Chahal CAA, Khanji MY

JACC: Cardiovascular Imaging 2023 PMID: 37480905

Eyes and the Heart – What a Clinician Should Know

Ng JY, Zarook E, Nicholson L, Khanji MY, Chahal CAA

Heart 2023 PMID: 37507215

Prediction of Stroke in Heart Failure: Is There a “One Size Fits All” Approach?

Lam PH, Chahal CAA.

Circulation: Heart Failure 2023 https://doi.org/10.1161/CIRCHEARTFAILURE.123.010762

2022

The Frequency, Penetrance and Variable Expressivity of

Dilated Cardiomyopathy-Associated Putative Pathogenic Gene Variants in UK Biobank Participants

*Shah RM, *Asatryan B, Sharaf Dabbag G, Aung N, Khanji MY, Lopes LR, van Duijvenboden, Holmes A, Muser D, Landstrom AP, Lee AM, Arora P, Semsarian C, Somers VK, Tiku-Owens A, Munroe PB, Petersen SE, Chahal CAA.

Circulation 2022 PMID: 35708014

The pathogenesis and long-term consequences of COVID-19 cardiac injury State-of-the-Art Review

Sirpanthong B, Asatryan B, Hanff TC, Chatha SR, Khanji MY, Ricci F, Muser D, Ferrari VA, Nazarian S, Santangeli P, Deo R, Cooper LT, Mohiddin SA, Chahal CAA.

Journal of the American College of Cardiology: Basic to Translational Science 2022 PMID: 35165665

2020

The relationship between anemia and sudden cardiac death in severe aortic stenosis

*Ducharme-Smith A, *Chahal CAA, Sawatari H, Podboy A, Sherif A, Scott CG, Brady PA, Gersh BJ, Somers VK, Nkomo VT, Pellikka PA.

American Journal of Cardiology, 2020. *co first-author PMID: 32946861

2019

Risk Stratification in Arrhythmogenic RV Cardiomyopathy/ Dysplasia Without an ICD

Chahal AA, Reza N, Santangeli P.

Expert Analysis, JACC 2019.

Pending

CT-Guided Direct Current Cardioversion for Atrial Arrhythmias During the COVID-19 Pandemic

Mahdi Veillet-Chowdhury, MD, Ghaith SharafDabbagh, MD ... Edmond Obeng-Gyimah, MD, FACC

Pending publication in JACC imaging (one of senior authors).

2021

Ischemic Ventricular Tachycardia: Multirnodality Imaging in Precision ablation Guidance

Mahdi Veillet-Chowdhury, MD, Ghaith SharafDabbagh, MD, Edmond Obeng-Gyimah, MD, Anwar Chahal, MBChB, MRCP, PhD

Journal of Cardiovascular Computed Tomography, March 2021

Implantable Loop Recorder for Augmenting Detection of New Onset Atrial Fibrillation in Patients Undergoing Typical Flutter Ablation

Gary Peng, MD PhD, Aung N. MD, Edmond Obeng-Gyimah, MD, ... Sanjay Dix.it MD

Heart Rhythm 02, Vol 2, No 3, June 2021

2018

Reversal of Pacing-Induced Following CRT

Khurshid, S, Obeng-Gyimah, E, Supple GE, Schaller R, Owen AT, Epstein AE, Marchlinski FE, Frankel DS

JACC Clin Clectrophysiol. 2018 Feb; 4(2):168-177

2010

Analysis of the Interactions between C-terminal Cytoplasmic Domains of KCNQI and KCNEI

Zheng, R., Keith, T., Obeng-Gyimah, E, ... McDonald, T.

Biochem. J. (2010) 428(1) 75-84

2005

Localization of a Disease Associated Mutation Site on the Three-Dimensional Structure of the Cardiac Ryanodine Receptor

Liu, Z., Wang, R, ... W.S.R., Wagenknecht

Acknowledgements: E. Obeng-Gyimah

Re: Image Processing. J Biol Chem. 2005 November 11; 280(45): 3791-3794

1991

Long Term Outcome of Patients with Non-ischemic Dilate, Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators

Fazio, Gregory; Veltri, E.; Tomaselli, G; Griffith, L.; Guarnieri, T.

PACE 12:11, 1905 -1909, November 1991

Implantable, Cardioverter Defibrillators, The Second Decade

Fazio, Gregory: Ventri, Enrico

Current Opinion in Cardiology, 1991, 6:72-77.

The Natural History of Dual Chamber Pacing

Hummel, John; Fazio, Gregory; Lawrence; Midel, M.; Brinker, J.

CE 14:11, 1745-1747.

2021-Present

ACURATE IDE: Transcatheter Replacement of Stenotic Aortic Valve through Implantation of ACURATE in Subjects Indicated for TAVR

Sponsor, Boston Scientific

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

Small Annuli Randomized to Evolut or Sapien Trial (SMART Trial)
Medtronic Evolut™ PRO and PRO+ Systems

Sponsor, Medtronic, Inc.

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Co-Investigator

OPTIMIZE PRO TAVR Post Market Study Medtronic Evolut™Medtronic Evolut™PRO+ System

Sponsor, Medtronic, Inc.

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

2017-Present

ASAP-TOO: A Prospective, Randomized, Controlled, Multi-Center Study to evaluate the safety and effectiveness of left atrial appendage occlusion with the WATCHMAN Device in prevention of stroke and bleeding in patients with atrial fibrillation in whom the risk of taking systemic anticoagulation is prohibitive

Sponsor, Boston Scientific Corp.

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

WATCH-TAVR: A prospective, randomized, controlled, multi-center study to evaluate the safety and effectiveness of left atrial appendage occlusion with the WATCHMAN Device in prevention of stroke and bleeding in patients with atrial fibrillation undergoing transcatheter aortic valve replacement

Sponsor, Boston Scientific Corp.

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

TAVR Unload: Transcatheter Aortic Valve Replacement to Unload the Left Ventricle in Patients with Advanced heart failure: a randomized trial

Sponsor, Cardiovascular Research Foundation (CRF)

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

EARLY TAVR: A Prospective, Randomized, Controlled, Multi-Center Study to compare the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve vs. Surveillance in Asymptomatic Patients who have Severe, Calcific, Aortic Stenosis

Sponsor, Edwards LifeScience, LLC

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

2016-Present

PARTNER 3: A Prospective, Randomized, Controlled, Multi-Center Study to Establish the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low-Risk Patients Requiring Aortic Valve Replacement who have Severe, Calcific, Symptomatic Aortic Stenosis

Sponsor, Edwards LifeSciences, LLC

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Sub-Investigator

Amplatzer Amulet LAA Occluder Trial: A Prospective, Randomized, Controlled, Multi-Center Study to compare the Safety and Efficacy of the Amplatzer Amulet LAA Occluder Device versus the WATCHMAN LAA Occluder Device for the prevention of stroke in patient with non-valvular atrial fibrillation

Sponsor, Abbott Vascular, LLC

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Sub-Investigator

Pending TAVR Project: Use of General Anesthesia vs. IV sedation in TAVR patients: A Two-Centered Retrospective Analysis

Sponsor, St. Lukes: TAVR Project Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

2021-2022

A Retrospective, Multi-Center, Real -World Study Assessing the Clinical Use of BARD Aortic Valvuloplasty Catheters (CSA True Flow Retrospective Clinical Study)

Sponsor, Bard Peripheral Vascular, Inc.

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Principal Investigator

2016-2022

PARTNER II/SAPIEN 3/S3iCAP/S3iCAP2: Trans Aortic Valve Replacement Clinical Study

Sponsor, Edwards LifeSciences, LLC

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Sub-Investigator

2018-2021

PINNACLE FLX: Protection against Embolism for non-valvular AF Patients: Investigational Device Evaluation of the WATCHMAN FLX LAA Closure Technology

Sponsor, Boston Scientific Corporation

Heart & Vascular Research, WellSpan York Hospital, York PA

Role: Sub-Investigator

EVOLVE 48: A Prospective Multicenter Single Arm Trial to Assess the Safety and Effectiveness of the SYNERGY 48 mm Everolimus-Eluting Platinum Chromium Coronary Stent System for the Treatment of Subjects with Atherosclerotic Lesion(s).

Sponsor, Boston Scientific Corporation

Heart & Vascular Research, WellSpan York Hospital, York PA

Role: Sub-Investigator

2018-2019

NovaCross: A Prospective, Multi-Center, Non-randomized, Single arm, Open label, Pivotal Study to Evaluate the Safety and Effectiveness of the NovaCross Micro-catheter in Facilitating Crossing Chronic Total Occlusion (CTO) Coronary Lesions

Sponsor, NitiLoop

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Sub-Investigator

2017-2019

PRECISION GRX Registry: A Multicenter Post-Market Registry for the Evaluation of the CorPath GRX System Effectiveness in Percutaneous Coronary Interventions.

Sponsor, Corindus Vascular Robotics, Inc.

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Sub-Investigator

2016-2017

CrossBoss First Trial: Randomized Comparison of a CrossBoss First vs. Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion

Sponsor, Boston Scientific Corp.

Heart & Vascular Research, WellSpan York Hospital, York, PA

Role: Sub-Investigator

2015-2016

ARTEMIS: Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study

Assess the impact of copayment reduction, by equalizing the copayments for clopidogrel and ticagrelor.

Division of Cardiology, Lancaster General Health, Lancaster, PA

Role: Sub-Investigator

TURBULENCE: Clinical Evaluation of the Cadence Device in Detection of Coronary Artery Diseases

Evaluate the accuracy of the Cadence Device in identifying the existence of clinically significant coronary artery disease.

Division of Cardiology, Lancaster General Health, Lancaster, PA

Role: Sub-Investigator

2014-2016

Percutaneous Ventricular Restoration in Chronic Heart Failure due to Ischemic Heart Disease

Participated in the PARACHUTE IV Trial to establish efficacy and long-term safety of the parachute implant system.

Division of Cardiology, Lancaster General Health, Lancaster, PA

Role: Sub-Investigator

2023

CT-guided direct current cardioversion for atrial arrhythmias during the COVID-19 pandemic

Veillet-Chowdhury M, Dabbagh GS, Benton SM, Hill AM, Lee JH, Singleton MJ, Fazio GP, Harvey JH, Samady H, Singh D, Khanji MY, Nazarian S, Pugliese F, Obeng-Gyimah E, Schuler BT, Chahal CAA.

JACC Cardiovasc Imaging 16(1):135-137, Jan, 2023. PMID 36599561.

Evaluation of lead-based echodensities on transesophageal echocardiogram in patients with cardiac implantable electronic devices

Patel NJ, Singleton MJ, Brunetti R, Richardson KM, Bhave PD.

J Cardiovasc Electrophysiol 34(1): 7-13, Jan, 2023. PMID 36317461.

Multicenter analysis of atrioesophageal fistula rates before and after adoption of active esophageal cooling during atrial fibrillation ablation

Sanchez J, Woods C, Zagrodzky J, Nazari J, Singleton M, Schricker A, Ruppert A, Brumback B, Jenny B, Athill C, Joseph C, Shah D, Upadhyay G, Kulstad E, Cogan J, Leyton-Mange J, Cooper J, Tamirisa K, Omotoye S, Timilsina S, Perez-Verdia A, Kaplan A, Patel A, Ro A, Corsello A, Kolli A, Greet B, Willms D, Burkland D, Castillo D, Zahwe F, Nayak H, Daniels J, MacGregor J, Sackett M, Kutayli M, Barakat M, Percell R, Akrivakis S, Hao SC, Liu T, Panico A, Ramireddy A, Lanes DB, Sze E, Francisco G, Silva J, McHugh J, Sung K, Feldman L, Serafini N, Kawasaki R, Hongo R, Kuk R, Hayward R, Park S, Vu A, Henry C, Bailey S, Mickelsen S, Taneja T, Fisher W, Metzl M.

medRxiv preprint Feb 23, 2023. PPR620459.

Look before you place: A bizarre ECG artifact due to lead placement

Brock J, Schmitt A, Bhave P, Whalen SP, Simmons T, Singleton M, Shantha G. Am J Emerg Med 67(194):e7-e10, May, 2023. PMID 36997382.

Anatomical location of leadless pacemaker and the risk of pacing-induced cardiomyopathy

Shantha G, Brock J, Singleton M, Kozak P, Bodziock G, Bradford N, Deshmukh A, Liang JJ, Pothineni NVK, Hranitzky P, Whalen P, Bhave PD.

J Cardiovasc Electrophysiol 34(6):1418-1426, Jun, 2023. PMID 37161942.

Role of dofetilide in patients with ventricular arrhythmias

Shantha G, Singleton M, Kozak P, Bodziock G, Atreya AR, Narasimhan B, Deshmukh A, Liang JJ, Hranitzky P, Whalen P, Bhave P.

J Interv Card Electrophysiol . PMID 37247098.

2022

Inappropriate implantable cardioverter defibrillator therapy with the use of an underbody electrosurgery dispersive electrode

Singleton MJ, Fernando RJ, Bhave PD, Clark JR, Johnson JE, Whalen SP, Royster RL.

J Cardiothorac Vasc Anesth 36(1):236-241, Jan 1, 2022. PMID 33745836.

Atrial fibrillation and risk of incident heart failure with reduced versus preserved ejection fraction

Nicoli CD, O’Neal WT, Levitan EB, Singleton MJ, Judd S, Howard G, Safford M, Soliman EZ.

Heart 108(5):353-359, Mar, 2022. PMID 34031160.

Left atrial stiffness independently predicts exercise intolerance and quality of life in older, obese patients with heart failure with preserved ejection fraction

Singleton MJ, Nelson MB, Samuel TJ, Kitzman DK, Brubaker P, Haykowsky MJ, Upadhya B, Chen Haiying, Nelson MD.

J Card Fail 28(4):567-575, Apr, 2022. PMID 34774747.

Comparison of bonus dosing of methohexital and propofol in elective direct current cardioversion

Beaty EH, Fernando RJ, Jacobs ML, Winter GG, Bulla C, Singleton MJ, Patel NJ, Bradford NS, Bhave PD, Royster RL.

J Am Heart Assoc 11:e026198, Sept 21, 2022. PMID 36129031.

Opportunities and challenges in heart rhythm research: Rationale and development of an electrophysiology collaboratory

Nguyen DT, Bilchick KC, Narayan SM, Chung MK, Thomas KL, Laurita KR, Vaseghi M, Sandhu R, Chelu MG, Kannankeril PJ, Packer DL, McManus DD, Verma A, Singleton M, Tarakji K, Al-Khatib SM, Kaltman JR, Balijepalli RC, Van Hare GF, Hurwitz JL, Russo AM, Kusumoto FM, Albert CM.

Heart Rhythm 19(11):1927-1945, Nov, 2022.

2021

The Utility of silent myocardial infarction on electrocardiogram as an ASCVD risk enhancer for primary prevention: The Multi-Ethnic Study of Atherosclerosis

Singleton MJ, German CG, Soliman EZ, Burke GL, Yeboah J.

J Electrocardiol 65: 105-109, Feb 2, 2021. PMID 33588257.

Assocation of T-wave abnormalities with major cardiovascular events in diabetes: The ACCORD trial

Mould SJ, Soliman EZ, Bertoni AG, Bhave PD, Yeboah J, Singleton MJ.

Diabetologia 64(3): 504-511, Mar, 2021. PMID 33420509.

Cardiac tumor masquerading as ST elevation myocardial infarction: A Case report and literature review

Xiang K, Bhave PD, Whalen SP, Singleton MJ.

J Clin Cases and Reports 4 (2):39-42, Apr 1, 2021. PMID: 33367223.

An incessant tachycardia: What is the mechanism?

Singleton MJ, Koneru JN, Bhave PD, Whalen SP.

J Innov Card Rhythm Manag 12(4):4477-4481, April, 2021. PMID 33959407.

The storm before the calm: ablation of premature ventricular complex trigger for incessant ventricular fibrillation

Singleton MJ, Bhave PD, Beaty EH, Bradford NS, Whalen SP.

J Innov Card Rhythm Manag 12(5):4501-4505, May 15, 2021. PMID 34035982.

New-onset atrial fibrillation incidence and associated outcomes in the medical intensive care unit

Brunetti R, Zitelny E, Newman N, Bundy R, Singleton MJ, Dowell J, Dharod A,

Bhave PD.

Pacing Clin Electrophysiol 44(8):1380-1386, Aug, 2021. PMID 34173671.

Multiple blood biomarkers and stroke risk in atrial fibrillation: The REGARDS study

Singleton MJ, Yuan Y, Dawood FZ, Howard G, Judd SE, Zakai NA, Howard VJ, Herrington DM, Soliman EZ, Cushman M.

J Am Heart Assoc 10(15): e020157, Aug 3, 2021. PMID 34325516.

Trajectories of blood pressure control a year after randomization and incident cardiovascular outcomes in SPRINT

German CA, Elfassy T, Singleton MJ, Rodriguez CJ, Ambrosius WT, Yeboah J.

Am J Hypertens 34(9):973-980, Sept 22, 2021. PMID 33861306.

Physical activity, coronary artery calcium, and cardiovascular outcomes in the Multi-Ethnic Study of Atherosclerosis (MESA)

German CA, Fanning J, Singleton MJ, Shapiro MD, Brubaker PH, Bertoni AG, Yeboah J.

Med Sci Sports Exerc 54(5):800-806, Dec 30, 2021. PMID 34967800.

2020

Association of silent myocardial infarction with major cardiovascular events in diabetes: The ACCORD trial

Singleton MJ, German CA, Bertoni AG, Ambrosius WT, Bhave PD, Soliman EZ, Yeboah J.

Diabetes Care 43 (4):e45-46, Apr, 2020. PMID: 32179509.

Management of ventricular arrhythmias in patients with LVAD

Maradey J, Singleton MJ, O’Neill TJ, Bhave PD.

Curr Opin Cardiol 35 (3):289-294, May, 2020. PMID: 32205476.

P-wave axis is associated with all-cause mortality in diabetes: The ACCORD trial

Ehrhardt-Humbert L, Upadhya B, Bhave PD, Soliman EZ, Beaty EH, Yeboah J, Singleton MJ.

J Electrocardiol 60:184-187, May 1, 2020. PMID: 32413693.

Association of atrial fibrillation without cardiovascular comorbidities and stroke risk: from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study

Singleton MJ, Imtiaz-Ahmad M, Kamel H, O’Neal WT, Judd SE, Howard VJ, Howard G, Soliman EZ, Bhave PD.

J Am Heart Assoc 9(12): 1-10, June 4, 2020. PMID: 32495723.

Third-degree burns caused by transcutaneous pacing for third-degree heart block

Singleton MJ, Schoenfeld MH, Bhave PD, Beaty EH, Whalen SP.

HeartRhythm Case Rep 6(8):495-498, May 18, 2020. PMID 32817826.

Association of P-wave axis with incident atrial fibrillation in diabetes mellitus: The ACCORD trial

Dhaliwal KK, Upadhya B, Soliman EZ, Beaty EH, Yeboah J, Bhave PD, Whalen SP, Singleton MJ.

Am J Cardiol 128(1):191-195, Aug 1, 2020. PMID: 32650919.

Atrial cardiopathy and stroke mortality in the general population

Ahmad MI, Singleton MJ, Bhave PD, Kamel H, Soliman EZ.

Int J Stroke 15(6):650-656, Aug, 2020; PMID: 31530133.

Objectively measured physical activity and the risk of atrial fibrillation: The REGARDS study

O’Neal WT, Bennett A, Singleton MJ, Judd S, Howard G, Howard VJ, Hooker S, Soliman EZ.

Am J Cardiol 128:107-11, Aug 1, 2020. PMID 32650902.

Prognostic significance of BMI-adjusted criteria for left ventricular hypertrophy

Afify H, Lee HL, Soliman EZ, Singleton MJ.

J Clin Hypertens 22(8): 1,476-1,483, Aug 6, 2020. PMID: 32762125.

Association of alcohol intake with hypertension in type 2 diabetes: The ACCORD trial

Mayl JJ, German CA, Bertoni AG, Upadhya B, Bhave PD, Yeboah J, Singleton MJ. J Am Heart Assoc 9(18): 1-8, Sep 9, 2020. PMID: 32900264.

Effect of intensive glycemic and blood pressure control on QT prolongation in diabetes: The ACCORD trial

Singleton MJ, Soliman EZ, Bertoni AG, Whalen SP, Bhave PD, Yeboah J.

Diabetes 69(10): 2186-2193, Oct, 2020. PMID: 32732305.

The Big short: A Lifesaving alternative to a catastrophic lead failure

Kowal JL, Singleton MJ, Whalen SP, Bhave PD.

HeartRhythm Case Rep 6(11):831-835, Aug 4, 2020. PMID 33204616.

Effect of intensive blood pressure lowering on incident atrial fibrillation: A Systematic review and meta-analysis

Singleton MJ, Chen LY, Whalen SP, Bhave PD, Beaty EH, Yeboah J, Soliman EZ.

J Atr Fibrillation 13(4):1-6, Jan, 2021. PMID *** (in press).

Body mass index, sex, and incident atrial fibrillation in diabetes: The ACCORD trial

Singleton MJ, German CA, Soliman EZ, Whalen SP, Bhave PD, Bertoni AG, Yeboah J.

JACC Clin Electrophysiol 6(13):1713-1720, Dec 14, 2020. PMID 33334452.

Prognostic value of Goldberger’s electrocardiographic triad for left ventricular dysfunction

Xiang KR, Soliman EZ, Bhave PD, Singleton MJ.

J Electrocardiol 64:18-22, Nov 27, 2020. PMID 33278775.

Race, body mass index, and the risk of atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis

Singleton MJ, German CA, Carnethon M, Soliman EZ, Bertoni AG, Yeboah J.

J Am Heart Assoc 10(1): 1-10, Jan 5, 2021. PMID 33382342.

Vital role of transesophageal echocardiographic surveillance of a left atrial appendage perforation complicating attempted left atrial appendage occlusion

Zitelny E, Brunetti R, Beaty EH, Singleton MJ, Richardson K.

CASE: 5(1):7-11, Oct 31, 2020. PMID: 33644506.

2019

Relation of minor electrocardiographic abnormalities to cardiovascular mortality

Hari KJ, Singleton MJ, Ahmad MI, Soliman EZ.

Am J Cardiol. 2019 May 1;123(9):1443-1447. PMID: 30792000.

Lead extraction complicated by right ventricular pseudoaneurysm: Percutaneous closure with septal occluder device

Singleton MJ, Brunetti R, Schoenfeld MH, Bhave PD, Zhao DX, Whalen SP.

HeartRhythm Case Rep 5 (11):542-544. Nov, 2019. PMID: 31890569, PMC6926237.

QRS duration is associated with all-cause mortality in type 2 diabetes: The Diabetes Heart Study

Singleton MJ, German C, Hari KJ, Saylor G, Herrington DM, Soliman EZ, Freedman BI, Bowden DW, Bhave PD, Yeboah J.

J Electrocardiol 58:150-154, Nov 28, 2019. PMID: 31895990.

2018

Bioprosthetic tricuspid valve thrombosis: Percutaneous PFO closure to improve hypoxia and respiratory failure

Flueckiger P, Singleton M, Vasu S, Zhao D.

Catheter Cardiovasc Interv. 2018 Nov 1;92(5):993-997. PMID: 29068163.

2017

Relation of higher resting heart rate to risk of cardiovascular versus noncardiovascular death

*Alhalabi L, Singleton MJ, Oseni AO, Shah AJ, Zhang ZM, Soliman EZ. (shared first authorship)

Am J Cardiol. 2017 Apr 1;119(7):1003-1007. PMID: 28132682.

Association between QT-interval components and sudden cardiac death: The ARIC study (Atherosclerosis Risk in Communities)

O'Neal WT, Singleton MJ, Roberts JD, Tereshchenko LG, Sotoodehnia N, Chen LY, Marcus GM, Soliman EZ.

Circ Arrhythm Electrophysiol. 2017 Oct;10(10). PMID: 29030380, PMC5659833.

2015

Pre-implant assessment for optimal LV lead placement in CRT: ECG, ECHO, or MRI?

Singleton MJ, Spragg DD.

J Atr Fibrillation. 2015 Aug-Sep;8(2):1280. doi: 10.4022/jafib.1280. eCollection 2015 Aug- Sep. PMID: 27957193, PMC5135171.

2009

Development of spike-wave seizures in C3H/HeJ mice

Ellens DJ, Hong E, Giblin K, Singleton MJ, Bashyal C, Englot DJ, Mishra AM, Blumenfeld H.

Epilepsy Res. 2009 Jul;85(1):53-9. doi: 10.1016/j.eplepsyres.2009.01.007. Epub 2009 May 5. PMID 19409755, PMC3432281.

2009

InVivo Assessment of Blood Flow Patterns in Abdominal Aorta of Mice with MRI: Implications for AAA Localization

Amirbekian S, Long RC, Consolini MA, Suo J, Willett NG, Fielden SW, Giddens DP, Taylor WR, Oshinski JN.

American Journal of Physiology. Heart and Circulatory Physiology. 297: H1290-H1295, 2009

1997

Cost Benefit Analysis of a 9-Centistoke Lubricant for Helicopter Transmissions

Cook TA, Consolini MA (United Technologies Corporation Sikorsky Aircraft Division)

Pentagon Report A001033, August 1997

2021

Temporary Mechanical Circulatory Support in Postinfarct Ventricular Septal Defect: Time for an Upgrade?

Patel NH, Gong T, & Rafael A.

JACC Cardiovascular Interventions. 2021 Sep 13. Vol 14: 1955

Transitioning HFrEF Patients on ACE Inhibitors to Modern Medical Therapy: What is the Next Step?

Patel NH & Bindra A.

JACC: Heart Failure. 2021 Apr 9. Vol 4: 319.

2020

Pulmonary Artery Pseudoaneurysm Associated with Abandoned Epicardial Defibrillator Patch

Hamadeh A, Patel NH, & Choi, JW.

American Journal of Cardiology. 2020 Aug 1. Vol. 128: 16-162.

2018

Inhibition of BKCa Negatively Affects Cardiac Function

Patel NH, Johaneson J, Shah K, Goswami SK, Patel NJ, Ponnalagu D, Kohut AR & Singh H.

Journal of Physiologic Reports. 2018 Jun 6. Vol. 6 no 12: 1-11

2016

Comprehensive Echocardiographic Assessment of the Right Ventricle in Murine Models

Kohut AR, Patel NH & Singh H.

Journal of Cardiovascular Ultrasound. 2016 Sep 23. Vol. 23 no. 3: 229-238.

2014

Aggregatibacter aphrophilus pacemaker endocarditis: a case report

Patel S, Patel NH, Borah A & Saltzman H.

BMC Research Notes. 2014 vol 8: 885.

2022

Gender Differences in Chronic Total Occlusion Percutaneous Coronary Interventions: Insights from the PROGRESS-CTO registry

Kostantinis S., Simsek B., Karacsonyi J., Davies, Rhian E., Brilakis, ES et al. Catheter Cardiovasc Interv. 2022; 1- 9. doi: 10.1002/ccd.30425

Intravascular Lithotripsy in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights from the PROGRESS-CTO registry

Kostantinis S., Simsek B., Karacsonyi J., Davies, Rhian E., Brilakis, ES et al. Catheter Cardiovasc Interv. 2022; 100: 512-519. doi: 10.1002/ccd.30354. PMID: 35916076.

Preprocedural coronary computed tomography angiography in chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS-CTO registry

Simsek, B., Davies, Rhian E., Brilakis, ES, et al.

International Journal of Cardiology. 2022 Aug 8. doi: 10.1016/j.ijcard.2022.08.027

Incidence, Mechanisms, Treatment, and Outcomes of Coronary Artery Perforation during Chronic Total Occlusion Percutaneous Coronary Intervention

Kostantinis, S., Davies, Rhian E., Brilakis, ES, et al.

The American Journal of Cardiology. August 23, 2022. doi: 10.1016/j.amjcard.2022.07.004

Body Mass index and chronic total occlusion percutaneous coronary intervention outcomes: Is overweight the new normal?

Simsek B., Kostantinis S., Karacsonyi J., Davies, Rhian E., Brilakis, ES et al.

The Journal of Invasive Cardiology. Abstract Only. doi: 10.1016/j.jscai.2022.100289

Predictors of success in primary retrograde strategy in chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS-CTO

Simsek, B., Davies, Rhian E., Brilakis, ES, et al.

Catheterization and Cardiovascular Interventions. May 26, 2022. doi: 10.1002/ccd.30228

Predicting Periprocedural Complications in Chronic Total Occlusion Percutaneous Coronary Intervention

Simsek B., Kostantinis S., Karacsonyi J., Davies, Rhian E., Brilakis, ES et al.

J Am Coll Cardiol Intv. 2022 Jul, 15 (14) 1413–1422.https://doi.org/10.1016/j.jcin.2022.06.007

Prevalence and outcomes of balloon undilatable chronic total occlusions: Insights from the PROGRESS-CTO

Simsek B., Davies Rhian E., Brilakis ES, et al.

Int J Cardiol. April 2022:S0167-5273(22)00573-3. doi: 10.1016/j.ijcard.2022.04.057. Epub ahead of print. PMID: 35483480.

Outcomes of chronic total occlusion percutaneous coronary intervention in patients with reduced left ventricular ejection fraction

Simsek B, Kostantinis S, Karacsonyi J, Davies, Rhian E., Brilakis, ES et al.

Catheterization and Cardiovascular Interventions. January 2022; (99)4:1059-1064. doi: http://dx.doi.org/10.1002/ccd.30097

2021

Subintimal tracking and reentry as a tool in CTO-PCI: Past, present, future

Davies, Rhian E., Rier J.D., McEntegart M., et al.

Catheterization and Cardiovascular Interventions. August 2021;(98)61144-1151. doi: https://doi.org/10.1002/ccd.29924. PMID: 34399015

2020

Training in High-Risk Coronary Procedures and Interventions: Recommendations for Core Competencies

Davies, Rhian E., Prasad M.P., Alaswad K., et al.

Catheterization and Cardiovascular Interventions. 2020;1–6. doi: https://doi.org/10.1002/ccd.29229. PMID: 32915494

Patient and Device Selection for Hemodynamic Support in High-Risk Percutaneous Coronary Intervention

Davies, Rhian E., Rier J.D., McCabe J.M.

Interventional Cardiology Clinics. October 2020;10(1):121–30. doi: https://doi.org/10.1016/j.iccl.2020.09.001. PMID: 33223101

A Novel Hybrid Approach to the Treatment of a Left Main Coronary Artery Aneurysm

Davies, Rhian E., Cheney, A.E., McCabe, J.M., et al.

JACC: Case Reports. September 2020;(2)11:1675-1678. doi: https://doi.org/10.1016/j.jaccas.2020.07.036. PMID: 34317032

#RadialFirst in CHiP and Cardiogenic Shock

Davies, Rhian E., Kearney, K.E., McCabe, J.M.

Interventional Cardiology Clinics. January 2020. doi https://doi.org/10.1016/j.iccl.2019.08.006. PMID: 31733740

2019

Percutaneous coronary intervention: Developments in the past 12 months

Davies, Rhian E., Abbott, J.D.

US Cardiology Review 2019;13(1):11-5. February 2019. https://doi.org/10.15420/usc.2019.1.1

Dorsal (Distal) Transradial Access for Coronary Angiography and Intervention

Davies, Rhian E., Gilchrist, I.C.

Interventional Cardiology Clinics. January 2019. https://doi.org/10.1016/j.iccl.2018.11.002. PMID: 30832936

2018

Gender Disparities in CAD: Women and Ischemic Heart Disease

Davies, Rhian E., Rier, J.D.

Current Atherosclerosis Reports. Sept 4, 2018. 20(10):51. doi: 10.1007/s11883-018-0753-7. PMID: 30178384

Contemporary Management of Post-MI Myocardial Rupture

Davies, Rhian E., Gilchrist I.C.

http://www.acc.org. Apr 16, 2018. http://www.acc.org/latest-in-cardiology/articles/2018/04/16/10/16/contemporary-management-of-post-mi-myocardial-rupture.

Contemporary Management of Post-MI Myocardial Rupture

Davies, Rhian E., Gilchrist IC

http://www.acc.org. Apr 16, 2018. http://www.acc.org/latest-in-cardiology/articles/2018/04/16/10/16/contemporary-management-of-post-mi-myocardial-rupture.

2017

Back Hand Approach to Radial Access: The Snuff Box Approach

Davies, Rhian E., and Gilchrist I.C.

Cardiovascular Revascularization Medicine (2017 Sep 1). pii:S1553-8389(17)30336-6. doi: 10.1016/j.carrev.2017.08.014. PMID: 29055660

Thin-walled access sheath to hold a larger guide: New technology specifically for transradial access

Davies, Rhian E., and Gilchrist I.C.

Catheterization and Cardiovascular Interventions (2017): 1020/1021. doi: 10.1002/ccd.27079. PMID: 28488409

Controversies in complex percutaneous coronary intervention: Radial versus Femoral

Gilchrist, I.C., Awour, S.O., Davies, Rhian E., Ukaigwe, A.C.

Expert Review of Cardiovascular Therapy, Volume 15, Issue 9, 27 July 2017, Pages 695-704. doi: 10.1080/14779072.2017.1358613. PMID:28730857

The Benefits and Risks of Oral Antiplatelet Therapy in Patients with Acute Coronary Syndrome

Davies, Rhian E., Ahmad, T., Alagona, P.

The Journal of Family Practice. Volume 66, Issue 2. 1 March 2017. http://www.mdedge.com/jfp/custom/JFP_CV3_Landing

2016

Comparison of the Effectiveness of Stress Echocardiography Versus Myocardial Perfusion Imaging in Patients Presenting to the Emergency Department with Low-Risk Chest Pain

Davies, Rhian E., Guodong L., Sciamanna C., Davidson Jr. W., Leslie D.L., Foy A.J.

The American Journal of Cardiology, Volume 118, Issue 12, 15 December 2016, Pages 1786-1791, ISSN 0002-9149. doi: 10.1016/j.amjcard.2016.08.066. (PMID: 27865485)

It's Still Important, Just Doesn't Hurt

Davies, Rhian E., and Gilchrist I.C.

Catheterization and Cardiovascular Interventions 87.5 (2016): 875-76. doi: 10.1002/ccd.26537. PMID: 27085028

To Neither Bleed nor Clot: That is the Question

Davies, Rhian E., and Gilchrist I.C.

Catheterization and Cardiovascular Interventions (2016). doi: 10.1002/ccd.26714. PMID: 27619744

2015

Association of Intimate Partner Violence and Health-care Provider-identified Obesity

Davies, Rhian E., Lehman E., Perry A., and McCall-Hosenfeld J.S.

Women & Health 56.5 (2015): 561-75. doi: 10.1080/03630242.2015.1101741. PMID: 26495745

Positive Predictive Value of an Elevated Cardiac Troponin for Type I Myocardial Infarction in ED Patients Based on the Chief Complaint

Maag R., Sun S., Hannon M., Davies Rhian E., Alagona P., and Foy A.

The American Journal of Emergency Medicine 33.4 (2015): 516-20. doi: 10.1016/j.ajem.2015.01.003. PMID: 25680564

2014

Association of Intimate Partner Violence and Health-care Provider-identified Obesity

Davies, Rhian E., Lehman E., Perry A., and McCall-Hosenfeld J.S.

Journal of Women’s Health 23(4). doi: 10.1089/jwh.2014.Ab01.abstracts.

2020

Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic.
Bradley D. Allen, Timothy C. Wong, Chiara Bucciarelli-Ducci, Jennifer Bryant, Tiffany Chen, Erica Dall’Armellina, J.Paul Finn, Marianna Fontana, Marco Francone, Yuchi Han, Allison G. Hays, Ron Jacob, Chris Lawton, Warren J. Manning, Karen Ordovas, Purvi Parwani, Sven Plein, Andrew J. Powell, Subha V. Raman, Michael Salerno, James C. Carr
J Cardiovasc Magn Reson. 2020 Aug 10;22(1):58.

Rapid Cardiac MRI Protocols: Feasibility and Potential Applications
Katia Menacho-Medina, Ntobeko A. B.Ntusi, James C. Moon, J. Malcolm Walker, Ron Jacob

Current Radiology Reports volume 8, Article number: 2 (2020)

2019

Arterial Properties as Determinants of Left Ventricular Mass and Fibrosis in Severe Aortic Stenosis: Findings
Julio A. Chirinos, MD, PhD, FAHA;* Scott R. Akers, MD, PhD;* Erik Schelbert, MD, MS; Bradley S. Snyder, MS; Walter R. Witschey, PhD; Ron M. Jacob, MD; Carlos Jamis-Dow, MD; Bilal Ansari, MD; Jonathan Lee; Patrick Segers, PhD; Mitchell Schnall, MD, PhD; Joao L. Cavalcante, MD
From ACRIN PA 4008. J Am Heart Assoc. 2019 Jan 8;8(1)

2018

Why CMR Online resources – Pericardial Disease.
Jacob R, Mukai, K

2007

A practical approach to the quantification of valvular regurgitation.

Jacob R, Stewart WJ.

Curr Cardiol Rep. 2007 Apr;9(2):105-11.

2005

SCMR Level II/Independent Practitioner Training Guidelines for Cardiovascular Magnetic Resonance: Integration of a Virtual Training Environment.

Amit R. Patel, Sebastian Kelle, Marianna Fontana, Ron Jacob, Jadranka Stojanovska, Jeremy Collins, Hena Patel, Marco Francone, Chiara Bucciarelli-Ducci, Subha Raman, Gaby Weissman.

Representing the Virtual Training Taskforce of the Society of Cardiovascular Magnetic Resonance

Improving CMR access in Low-Middle Income Countries for Cardiomyopathy Assessment and Improved Cardiac Care: Rapid CMR

K. D. Menacho, S. Ramirez, A. Perez, L. Dragonetti, D. Perez de Arenaza, DI. Katekaru, V. Illatopa, S. Munive, B. Rodriguez, A.C Shimabukuro, K. Cupe, R. Bansal, V Bhargava, I. Rodriguez, A. Seraphim, K. Knott, A. Abdel-Gadir, S. Guerrero, M. Lazo, D. Uscamaita, M. Rivero, N. Amaya, S. Sharma, A. Peix, T. A. Treibel, C. Manisty, S. Mohiddin, H. Litt, Y. Han, J. Fernandes, R. Jacob, M. Westwood, N.A.B. Ntusi A.S. Herrey, J.M. Walker, J. C Moon. (Submitted for publication)

2021

Intraprocedural Hybrid Cardiac Computed Tomography for Left Atrial Appendage Occlusion: A Concept and Feasbility Study

Veillet-Chowhury M, Benton SM, Chahal AA, Harvey JE, Tolerico P, Nicholson W, Sharaf Dabbagh G, Pugliese F, Khanji M, Nazarian S, Schuler B.

JACC Interventions. 2021 Aug;14(16):1852-1853.

Durability of Mitroflow Surgical Prosthesis for Surgical Aortic Valve Replacement Based on Prosthesis Size

Mir J, Tolerico P, Kaczorowski D, Benton SM, Nicholson W, Puri R, Harvey JE. CHEST. Accepted 2021, In press.

Virtual Teleproctoring for Chronic Total Occlusions Percutaneous Coronary Intervention: A Virtual Response to a Global Pandemic

Benton SM, Harvey JE, Schryver T, Tolerico P, Harjai K, Nicholson WM.

JACC Interventions. In press.

Early Feasibility Study of Intra-procedural Cardiac Computed Tomography (CT) for Left Atrial Appendage Occlusion

Veillet-Chowdhury M, Benton SM, Harvey JE, Tolerico P, Nicholson WM, Schuler B.

JACC. In press.

When Things Get Stuck: Gear Entrapment and Other Complications of CTO PCI

Benton SM; Nicholson WJ.

Interventional Cardiology Clinics. 2021 Jan;10(1):131-145.

2020

Challenging left atrial appendage closure using intraprocedural cardiac CT guidance

Veillet-Chowdhury M. Benton SM, Harvey JE, Nicholson WM, Schuler B. JACC Cardiovascular Interventions. 2020 May 25;13(10):e89-e91.

2019

Going to great lengths for durability in CTO PCI

Benton SM, Nicholson WJ.

Cardiovascular Revascularization Medicine. 2019 Dec; 20(12):1123-1124.

Acute catheter-induced subclavian artery thrombosis treated with endovascular stent graft placement and rheolytic thrombectomy: A case report and review

Tolerico P, Harvey JE, Benton SM, Patel M, Nicholson W.

Cardiovascular Revascularization Medicine. 2019 Nov; 20(11):s.

2018

Editorial: Orbital atherectomy: A portal opens

Benton SM, Kumar G.

Journal of Interventional Cardiology. 2018 Feb;31(1):21-22.

Noninvasive Derivation of Fractional Flow Reserve From Coronary Computed Tomographic Angiography: A Review

Benton SM, De Cecco C, Schoepf JU. Bayer RR.

Journal of Thoracic Imaging. 2018 Mar;33(2):88-96.

2017

A round valve in an oval hole: Right-sizing prosthetic aortic valves with preoperative computed tomography

Benton SM, Litwin S.

Circulation Cardiovascular Imaging. 2017 May;10(5):e006404.

2015

Incidence of complete heart block and procedural mortality in alcohol septal ablation for symptomatic hypertrophic cardiomyopathy: A 15-year experience

Benton SM, Rier JD, Neathawk J, Coker J, Kpaeyeh J, Yoe R, Litwin S, Nielsen C, Fernandes V.

Catheterization and Cardiovascular Interventions. 2015 May;85(2s): S145.

The impact of race and gender on procedural outcomes after alcohol septal ablation for symptomatic hypertrophic obstructive cardiomyopathy

Benton SM, Rier JD, Panuccio A, Shaji S, Griffin BE, Neathawk J, Litwin S, Nielsen C, Fernandes V.

Journal of the American College of Cardiology. 2015 Oct;66(15):B305-B306.

Outcomes among the elderly in alcohol septal ablation for symptomatic hypertrophic obstructive cardiomyopathy

Neathawk J, Benton SM, Rier JD, Shaji S, Griffin BE, Litwin S, Nielsen C, Fernandes V.

Journal of the American College of Cardiology. 2015;66(15):B8305-B8306.

Hemodynamics of stenotic aortic valve under the influence of contractility, preload, and afterload

Chiaramida S, Benton SM, Rier JD, Steinberg TB, Steinberg D, Sun Y.

Journal of the American College of Cardiology. 2015 Mar;65(10s):A1973.

Eosinophilic myocarditis-an unusual cause of left ventricular hypertrophy

Coffin ST, Benton SM, Lenihan DJ, Naftilan AJ, Mendes LA.

The American Journal of the Medical Sciences. 2015 Apr;349(4):358-362.

2014

Effect of transcutaneous aortic valve implantation on the Heyde's syndrome

Benton SM, Kumar A, Crenshaw M, Fredi JL.

The American Journal of Cardiology. 2014 Sep 15;114(6):953-954.

Clinical features of precocious acute coronary syndrome

Davidson L, Wilcox J, Kim D, Benton SM, Fredi J, Vaughan D.

The American Journal of Medicine. 2014 Feb;127(2):140-44.

2012

Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors

Ikonomidis JS, Ruddy JM, Benton SM, Spinale FG, et al.

Annals of Thoracic Surgery. 2012 Feb;93(2):457-63.

2010

Invasive thymoma with endobronchial metastasis

Benton SM, Rogers RP, Reed CE.

Annals of Thoracic Surgery. 2010 Feb;89(2):612-614.

Application process

We’ll accept applications starting in July 2024 for the fellowship class starting July 2025.

All applications must be submitted through the Electronic Residency Application Service (ERAS). Applications will not be reviewed outside of ERAS and positions will not be filled outside of the match.

Eligible candidates will be U.S. citizens, permanent residents or hold an acceptable visa (only H-1-B and J1 visa accepted) and have completed an internal medicine program that is accredited by the Accreditation Council for Graduate Medical Education (ACGME).

Candidates must be board-eligible or board certified in internal medicine and be eligible for a Pennsylvania medical training license.

Interviews will be conducted September through November 2024.

Application requirements

We only accept ERAS applications, which must include the following:

ERAS common application
CV
personal statement
three letters of recommendation (written within the last six months)
dean’s letter
transcripts
USMLE/COMLEX Step 1, 2 and 3 scores, if applicable
Educational Commission for Foreign Medical Graduates (ECFMG) Certification (if applicable; required by Jan. 30, 2025)

If you have any questions, contact Becky Foremny at 717-851-6594 or rforemny@wellspan.org.

Notice of Rights Under Federal Conscience and Anti-Discrimination Laws

WellSpan Health and all WellSpan Hospitals comply with applicable Federal conscience and antidiscrimination laws prohibiting exclusion, adverse treatment, coercion, or other discrimination against individuals or entities on the basis of their religious beliefs or moral convictions. You may have the right under Federal law to decline to perform, assist in the performance of, refer for, undergo, or pay for certain health care-related treatments, research, or services (such as abortion or assisted suicide, among others) that violate your conscience, religious beliefs, or moral convictions.

If you believe that WellSpan Health or any WellSpan Health Hospital has failed to accommodate your conscientious, religious, or moral objection, or has discriminated against you on those grounds, you can file a conscience and religious freedom complaint with the U.S. Department of Health and Human Services, Office for Civil Rights, electronically through the Office for Civil Rights Complaint Portal, available at https://ocrportal.hhs.gov/ocr/portal/lobby.jsf or by mail or phone at: U.S. Department of Health and Human Services, 200 Independence Avenue SW, Room 509F, HHH Building Washington, DC 20201, 1–800–368–1019, 800–537–7697 (TDD). Complaint forms and more information about Federal conscience and anti-discrimination laws are available at http://www.hhs.gov/conscience.

A copy of the complete rule and OCR’s explanatory text, as published in the Federal Register, is available at: https://www.govinfo.gov/content/pkg/FR-2019-05-21/pdf/2019-09667.pdf.

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Scholarly activity and application details